O P2 H O

Gly-79

Leu-81

FIGURE 10.7 Interaction of hydroxamic acid peptidomimetics with MMPs.

inhibitors have been disappointing and have led many investigators to conclude that MMPs are not suitable targets for the treatment of human cancer. On the contrary, it has been argued that because MMP inhibition would decrease the rate of tumor progression, the therapeutic benefit obtained from its administration would be minimized for patients undergoing clinical trials, who are normally at late stages of their disease.17

h3c o ^CHH3O

hon^Vh-vch3

N^XN.CH3

Batimastat

Marimastat

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