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Because of its high lipophilicity, it may cross the blood-brain barrier and it is effective against intracranial tumors. Another approach for designing more effective anthra-cyclines was directed to less basic compounds having a more stable glycosidic bond. One of them is anamycin,52 which after incorporation into liposomes went into clinical trials. In order to increase the topoisomerase II-mediated DNA cleavage, some groups have prepared 8- and 10-fluoroderivatives.53

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