Cleavable bond


Pteroic acid

Many folate-drug conjugates have been preclinically studied. The structure of one of these drugs, namely the EC-16-mitomycin C conjugate, is given. Among those that have reached clinical trials we will mention EC-145, which is a folate-targeted conjugate of a Vinca alkaloid in clinical stage development as a treatment for patients with refractory or metastatic folate-receptor positive cancers. Another example is EC-0225, which contains both a vinca alkaloid and a mitomycin C attached to a single folate molecule.


Folic acid co2h

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