Ont093 Oc144093

OC2H5

Laniquidar is a potent orally active MDR inhibitor that is undergoing Phase II clinical trials in metastatic breast cancer in combination with taxols.25 The triazi-neaminopiperidine derivative S-9788, which inhibits P-gp specifically with regard to MRPs, showed cardiac toxicity in Phase I clinical trials, but this drawback can be circumvented if this compound is combined with verapamil or PSC-833.26 Other P-pg inhibitors that are in advanced clinical trials as MDR modulators2,29 are SN-22995, ethacrynic acid, and irofulven.

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