P

p53 proteins, 277, 283, 298, 300, 308-309, 337, 345-346,354,388, 409, 411 activation by TS inhibitors, 23-24

Paclitaxel (taxol), 237-238, 390 analogues, 239-240 HMPA copolymer, 371 polyglumex conjugate, 373 SAR, 239-240 PALA, 11 Panitumumab, 264 PARP, 402, 405

inhibitors, 409-410 Patupilone, 241 PDGF, 259-265

inhibitors, 270 PD-115934, 214 PDEPT, 377-378 PDK1, 279-280

inhibitors, 280 PDT (see photodynamic therapy) PDX, 36 PDX-101, 333

PEG (polyethyleneglycol), 368 Pegaspargase (see PEG-l-asparaginase) Pegfilgrastim (see PEG-GCSF) PEG-camptothecin, 375 PEG-cytokine conjugates, 369 PEG-drug conjugates, 375 PEG-GCSF, 369 PEG-l-asparaginase, 368 PEG-recombinant arginine deiminase

(ADI-PEG20), 368 PEGylated liposomal doxorubicin (doxil), 382

PEGylated-glutaminase (PEG-PGA), 368 PEGylation of proteins, 368 Pemetrexed (alimta, LY-231514), 30, 38 Penclomedine, 128 Pentostatin (dCF), 42, 45 Peptidomimetics, 83, 290-291, 311, 313, 400 Perifosine, 279

Peroxisome proliferator activating receptors

inhibitors, 391-397 PHA-739358, 283 Pharmacogenetics, 2 Phosphatases in ADEPT, 366 Phosphatidylinositol-3-kinase (see PI3K) Phosphoramidases, 149 Phosphoramide mustard, 149 Phosphoribosylformylglycinamidine synthetase inhibitors, 39 Phosphoribosylpyrophosphate amidotransferase

(see PRPP amidotransferase) Phosphoroamidates, 342 Phosphorothioamidates, 342 Phosphorothioates, 342

Photodynamic therapy (PDT), 132-135

Photophrin, 133-134

Photosensitivity, 165

Photosensitizers, 132

Phthalascidin, 193

PI3K-AKT-mTOR pathway, 279

PI3K superfamily, 279, 411

PI-88, 317

Pibenzimol, 182

Pimonidazole, 131

Pipobroman, 173

Piposulfan, 159

Pirarubicin, 110

Piritrexim, 36

Pixantrone, 114, 215

PKC-412, 270, 284

PKC, 284-285

modulators, 284-286 Platelet-derived growth factor (see PDGF) Platinum complexes, 169-173 Plicamycin, 337 Plomestane, 68 PM00104/50,193 PNP, 18

PNU-159548,111 PNU-166945, 37 Podophyllotoxin, 216, 237 Poly(ADP-ribose)polymerase (see PARP) Poly-(l-glutamic) conjugates, 373 Polycythemia vera, 173 Polyelectrolyte effect, 201 Polyethylene glycol (see PEG) Polymer-directed enzyme prodrug therapy

(see PDEPT) Polymer therapeutics, 368 Polyprenoic acid, 89, 420 Porfiromycin, 131, 182, 357 Porphyrin, 133, 134 PPAR, 87, 89

selective modulators (SPPARMs), 421 Prednisone, 85 Prinomastat (AG3340), 315 PRO-001, 269 Procainamide, 329 Procarbazine, 166,168 Prodrug-based anticancer drug targeting, 352-367

Prodrugs activated by therapeutic radiation, 362

Proteasome, 297, 308 inhibitors, 307-312 Protein kinases in cancer, 252-254 Protoporphirin IX, 133

PRPP amidotransferase, 36

inhibitors, 36-37 Psammaplin A, 328 PSC-833 (valspodar), 392 Psoralens, 135 PTA, 42 PTK 787, 267

Purine biosynthesis inhibitors, 36 Purine nucleoside phosphorylase (see PNP) Purine nucleosides, 49-50 Pyrimidine nucleosides, 47-49 Pyroxamide, 333 Pyrrolo[1,4]benzodiazepines, 196

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