Penclomedine

Penclomedine, a 2-trichloromethylpyridine derivative, entered clinical trials for solid malignancies95 after initial observations of its strong antitumor properties in animal brain tumor models. It has been shown to be a DNA monoalkylating agent, and it has been proposed that its alkylating properties stem from the

Penclomedine

DNA alkylation

FIGURE 4.39 Generation of radicals from penclomedine.

Penclomedine

DNA alkylation

FIGURE 4.39 Generation of radicals from penclomedine.

homolytic cleavage of one of the C-Cl bonds by reductive microsomal metabolism (Fig. 4.39).

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