finding, clinical studies have shown that replacing DOX with EPI does not eliminate the risk of chronic cardiotoxicity. IDA, an analog of DNR obtained by removal of the methoxy group, has a broader spectrum of activity. This is probably related to its increased lipophilicity, which facilitates the cellular uptake and contributes to stabilize the ternary complex that forms the drug with DNA and topoisomerase II (see Chapter 7). The last effect is important, since a major mechanism of anthracycline activity depends on the formation of this complex. However, the cardiac safety of IDA has not been clearly established.

o^ih3co o ho J N
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment