R

Radical scavengers, 423-424

as inhibitors of RNR, 13 Radiochemotherapy, 127 Radioconjugate targeted agent, 377 Radiosensitizers, 129-130 Radiotherapy, 129 Raf proteins, 295 inhibitors, 295 Raloxifene, 60-61, 419 Raltitrexed (TOM), 30-31 Rapamycin (sirolimus), 281 Ras proteins, 286

inhibitors, 287-295 RARE (see retinoic acid response elements) Reactive oxygen species (see ROS) Rebeccamycin, 223 Rebimastat, 315

Reduced folate carrier, 28, 30-31, 35, 38-39 5a-Reductase inhibitors, 77 Reductively activated alkylating agents

(see bioreductive alkylation) Reductively activated quinones (see bioreductive activation) REPSA, 181 Resveratrol, 427

Retinoic acid response elements, 87 Retinoids, 86-87

in cancer chemoprevention, 419-420 Rexinoids, 86

RFC (see reduced folate carrier) RG-108, 330 RH132,156 RH3, 264

Ribonucleotide reductase (see RNR) Ribozymes, 269 Risedronate, 296 Rituximab, 343 Ro24-5531, 420

Romidepsin (FK-228, FR901228), 335

RNR, 11

catalytic cycle, 12-13 inhibitors, 13-18, 46 ROS, 93, 95, 299

as signaling molecules, 102 Roscovitine (seleciclib), 253 Rosiglitazone, 319 RSU-1069, 131, 359 Rubitecan, 221 Ruboxistaurin, 284

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