(LY-355703), which is in advanced clinical trials for the treatment of solid tumors.22 The cryptophycins are among the most potent antimitotic agents described, and their binding is very strong and poorly reversible, making them relatively exempt from efflux by the Pgp-170-mediated multidrug (MDR)-resis-tance mechanism.23 The somewhat related natural product maytansine 1 is another inhibitor of tubulin polymerization, about 1,000-fold more potent than vincristine. Although its toxicity led to abandoning clinical trials, it is now being considered as a candidate for antibody-drug conjugates (Chapter 11).


10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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