Rg108

Although X-ray crystallographic structures for human DNMT are not available, the extensive conservation of the catalytic domains of all DNMTs has allowed the use of X-ray structures of bacterial methylases as a basis for ligand design. The model thus derived was validated through the design and evaluation of a new nucleoside analog, namely, N4-fluoroacetyl-5-azacytidine,68 and also of nonnucleoside compounds, like RG-108.66 The binding of the previously mentioned natural inhibitor EGCG to this model65 is shown in Fig. 10.17.

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