Sh Sh

abstraction of the Cys-225 mercapto hydrogen by 2.7 to generate 2.8 in which the 3'-OH is deprotonated by Glu-441. The resulting enolate 2.9 evolves through partial protonation of the fluorine atom by Cys-439, which facilitates displacement of HF to give 2.10. Final abstraction of a hydrogen atom by the Cys-225 radical leads to the proposed final reaction product, the stable radical 2.11.

Gemcitabine (difluorodeoxycytidine, dFdC) is another nucleoside prodrug that has DNA polymerase inhibition as its primary mechanism of action (see Section 8.1), but it also has some activity as a RNR inhibitor.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment