N H 6-Mercaptopurine (MP)

6-Mercaptopurine requires intracellular metabolism by hypoxanthine guanine phosphoribosyl transferase (HGPRT) to be transformed into the thioinosinic acid, which shows cell cycle S-phase-specific cytotoxicity. Intracellular activation results in the inhibition of several enzymes belonging to the de novo purine synthesis pathway and misincorporation into DNA and RNA. Thus, thioinosinic acid, formed by incorporation of a ribose phosphate unit to MP catalyzed by HGPRT, inhibits PRPP amidotransferase, the first enzyme in the de novo synthesis of

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment