T

Tafluposide, 217 Talaporphin, 133-134 Tallimustine, 181

Tallysomycin S10b (TLM S10b), 117,

375-376 Tamoxifen, 58, 60, 64, 419 Tandutinib, 270 Tanespimycin, 301 Tanomastat (BAY 12-9566), 315 Tariquidar, 393 TAS-103, 204-205 Taxane site, 237 Taxanes, 237-240 Taxol (see paclitaxel) TDDP, 172 Telomerase, 337-338 inhibitors, 337-340 Telomestatin, 339 Temozolomide, 166, 403 Teniposide, 216, 390 Tensirolimus (CCI-779), 281 Testolactone, 70-71 Testosterone, 75

Tetrahydroisoquinoline alkaloids, 189-193 Tetrahydrouridine, 326-327 Tetraplatin, 171 Tezacitabine (FMdC), 15 Thalidomide, 321-322

Thiamiprine (guaneran), 42 Thioguanine (TG), 41 Thioinosinic acid, 41 Thiopurines, 41

Thiopurine methyltransferase (TPMT), 42, 44

Thiosemicarbazones, 13 Thiotepa, 154 Thrombospondins, 318 Thymidine phosphorylase (TP), 24 Thymidylate cycle, 19-20 Thymidylate synthase (TS), 18, 20

inhibitors, 21-31 Tipifarnib (R-115777), 291 Tirapazamine (TPZ), 126, 131, 355 TLK-117, 400 TLK-199, 400 TLK-286, 353 TNP-470, 322 TOM (see raltitrexed) Tomaymycin, 196 TOP-53, 217

Topoisomerases, 209-213 cleavable complex, 209 inhibitors, 212 poisons, 212 Topoisomerase I, 204, 209 inhibitors, 219-225 mechanism, 209 Topoisomerase II, 204, 209 catalytic inhibitors, 218-220 mechanism, 211 poisons, 128, 213-218 Topotecan, 221 Toremifene, 59 Tositumomab, 377

TPMT (see thiopurine methyltransferase)

TPZ (see tirapazmine) Trabectedin, 191 TRAIL, 298

Transition state analogs, 11, 18, 20, 43, 45, 318,

326-327, 330 Trapoxins A and B, 335 Trastuzumab, 264 Treosulfan, 158-159 Tretinoin, 87 Triapine, 13 1,3,5-Triazines, 167-339 Triazenes, 165 Triaziquone, 155 Tributyrin, 333

Trichostatin A (TSA), 333, 425 Triethylenemelamine (TEM), 154 Triethylenephosphoramide (TEPA), 154 Trilostane, 65

Trimelamol, 167, 169 Trimetrexate, 36 Trimidox, 14 Triptorelin, 82 Troglitazone, 89 TS (see thymidylate synthase) TSP-1, 318 Tubulin, 229-232

Tumor-associated carbonic anhydrase IX

(CA IX), 412 Tumorigenic events, 1

Tumor necrosis factor-related apoptosis-induced ligand (see TRAIL) Tumor suppressor gene (TP53), 298 Tyrosine kinases (TKs), 252, 254-274, 289

inhibitors, 254-275 Tyrosine mimics, 274 TUT-7 (see menogaril) Tyrphostin (AG-213), 258 TZT-1027, 234, 246

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