Several natural products have shown activity as angiogenesis inhibitors.47 The best studied, and one of the most potent angiostatic agents, is fumagillin, isolated from Aspergillus fumigatus and widely employed as an antifungal in Nosema apis infections in honeybees. Fumagillin is an inhibitor of methionine aminopeptidase-2,48 an enzyme involved in endothelial proliferation. It also inhibits the expression of the ETS1 transcription factor, which regulates the expression of VEGFs.49 Its toxicity prompted the preparation of analogs, and among them the most advanced one is TNP-470, which is being studied for several lymphomas, acute leukemias, and solid tumors. Because of neurotoxicity problems, conjugates of this compound have been developed in order to prevent its access through the blood-brain barrier.50

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10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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