R

R = PhCH2 Cemadotin R = C(CH3)3 Synthadotin

Hemiasterlin was originally reported from the South African sponge Hemias-terella minor, although it was soon also isolated from sponges of the genus Cym-bastela, together with the related hemiasterlins A and B. These agents inhibit tubulin assembly and probably bind at the ''peptide binding site'' shared with the dolastatins and cryptophycins.19 Many synthetic analogs of the hemiasterlins have also been developed, and HTI-286 is under clinical trials.20

H3C CH3 O

H3C CH3 O

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