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In a random screen carried out by the NCI in 1959,1-methyl-3-nitro-1-nitrosogua-nidine showed very weak antileukemic activity. Assay of analogs of this compound led to the discovery of the antitumor activity of 1-methyl-1-nitrosourea, the lead compound of the nitrosourea group. It was soon discovered that introduction of a 2-chloroethyl chain on the nitrogen atom bearing the nitroso group (CNUs) led to much increased activity. These chloroethyl derivatives were lipophilic enough to cross the blood-brain barrier and therefore were useful in the treatment

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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