Clinical Trials

In this review, we will focus on the larger prospective clinical trials that have tested the effect of AT supplementation on cardiovascular events in different populations. The seven clinical trials that will be discussed are as follows: (i) the ATBC Study, (ii) the CHAOS Study, (iii) the GISSI study, (iv) the HOPE Study, (v) the SPACE Study, (vi) the ASAP Study, and (vii) the PPP study. Although the HATS study is not a true vitamin E trial, it will be discussed because it has created much confusion.

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