Antipsychotic Drug Effects In An Animal Model Of Schizophrenia

As noted previously, the ability of antipsychotic drugs to stimulate dopaminergic transmission, particularly within the frontal cortex, has received a great deal of attention, in part, because of the notion that schizophrenic patients may have reduced cortical dopamine transmission.50,52 The concept of reduced cortical dopamine transmission and associated cognitive and behavioral effects has long been central to neurobiological hypotheses of schizophrenia49,51,61 and to animal models of the...

The Developmental Deregulation Model

While the type 1 type 2 model of schizophrenia provides a plausible explanation for the variation in degree of persistence of symptoms, the three-syndrome model provides a more satisfactory account of the heterogeneity of symptom type. In particular, the evidence supports the hypothesis that the pathophysiology of schizophrenia disrupts the function of a diverse set of cerebral sites and that the type of symptoms is largely determined by the nature of function of the affected cerebral regions....

Potency And Efficacy Of Antipsychotic Drugs

While all antipsychotics are affective against the florid symptoms of psychosis, they differ in the dosages required to achieve their palliative effects. Therefore, one of the oldest classification schemes for antipsychotic drugs is based on their potency. The potency of antipsychotic drugs has been traditionally expressed in equivalency units as compared to 100 mg of chlorpromazine, the prototypic antipsychotic drug.2 The drugs are usually divided into high, medium, and low potency groups. The...

References

Seeman, P., Dopamine receptor clinical correlate, in Psychopharmacology The Fourth Generation of Progress, Bloom, F. E. and Kupfer, D. J., Eds., Raven Press, Ltd., New York, 1995, chap. 26. 2. Seeman, P. and Niznik, H. B., Dopamine receptors and transporters in Parkinson's disease and schizophrenia, FASEB J, 4, 2737, 1990. 3. Weinberger, D. R., Implications of normal brain development for the pathogenesis of schizophrenia, Arch. Gen. Psychiatry, 44, 660, 1987. 4. Weinberger, D. R.,...

Typical And Atypical Medications

The most widely used property-based classification of antipsychotic medication divides them into typical and atypical drugs. Unfortunately, the parameters which distinguish typical from atypical drugs have not been well defined. The narrowest definition distinguishing typical from atypical drugs relates to their capacity to induce extrapyramidal side effects. All the earlier drugs, such as chlorpromazine, fluphenazine, thiothixene, and haloperidol, were found to have a strong tendency to...