phosphorylates key tyrosine residues within the cytoplasmic LepRb region (Y , Y , Y ), providing docking sites for binding of intra-cellular signalling components. In particular, STAT3 transcription factors bind to these activated SH2 domains at Y1138 and are phosphorylated, dimerised, and translocated to the nucleus where they alter transcription of target genes. Suppressor of cytokine signalling (SOCS3) is induced by pSTAT3 and acts to negatively regulate leptin signalling by inhibiting phosphorylation of the cytoplasmic tail of LepRb by JAK2

log. rwuroiwWm. S0CS3)

Fig. 3 Simplified diagrammatic overview of main intracellular pathway activated following leptin binding to LepRb. Upon leptin binding, JAK2 undergoes autophosphorylation and

0 0

Post a comment