Physicochemical drug interactions and incompatibilities

10.1 pH effects in vitro and in vivo 395 10.7 Adsorption of drugs 414 10.2 Dilution of mixed solvent systems 401 10.8 Drug interactions with plastics 417 10.3 Cation-anion interactions 402 10.9 Protein binding 419 10.4 Polyions and drug solutions 405 Summary 425 10.5 Chelation and other forms of Appendix 425 complexation 405 References 429 10.6 Other complexes 410 Further reading 430 This chapter deals with some practical consequences of the physical chemistry of drugs -particularly their...