Factors influencing solubility

Progress has been made in ways of predicting the solubility of solutes in aqueous media, both from estimates of their molecular surface area and from the nature of the key chemical groups in the parent structure. The importance of the surface area becomes clear if we think of the processes involved in the dissolution of a crystal (Fig. 5.1). The process can be

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Work w22

Solute

Removal of solute molecule

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