The half-life is therefore independent of the initial concentration of reactants.

Even in the case of a reaction involving more than one reacting species, the rate may still follow first-order kinetics. The most common example of this occurs when one of the reactants is in such a large excess that any change in its concentration is negligible compared with changes in the concentration of the other reactants. This type of reaction is termed a pseudo first-order reaction. Such reactions are often met in stability studies of drugs that hydrolyse in solution, the water being in such excess that changes in its concentration are negligible and hence the rate of reaction is dependent solely on the drug concentration.

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