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20 40 60 80 100 Percentage solubiliser in vehicle

20 40 60 80 100 (a) Percentage solubiliser in vehicle (b)

20 40 60 80 100 Percentage solubiliser in vehicle

Figure 9.25 (a) Drug partition coefficient and solubility dependence on vehicle composition for the 'ideal' case. (b) Predicted relative steady-state penetration (CvP ) as a function of vehicle composition for the 'ideal' case. Point A represents a formulation containing 1.0 mg g0 and 60% solubiliser. On threefold dilution with a base containing no solubiliser, point B is arrived at where CvP is higher.

Reproduced from B. J. Poulsen, in Drug Design, vol. 4 (ed. E. J. Ariens), Academic Press, New York, 1973.

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