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Matrix system with adhesive layer covering the entire underside

1) Backing foil

2) Drug reservoir

I. Membrane system

II. Matrix systems dd

Nitroderm TTS Transiderm Nitro

NitroDisc

NitroDur

(a) Support

(b) Layer of active principle

(c) Release-controlling membrane

(d) Layer of adhesive

(e) Protective film

3) Adhesive layer

4) Release liner

5) Control membrane

6) Opening tab

7 Alumi nium layer

Figure 8.40 The structures of some commercial transdermal membrane-controlled and matrix systems (the structure of the Deponit TTS is shown in Fig. 8.41).

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