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0 Reproduced from S. Agharkar, S. Lindenbaum and T. Higuchi, J. Pharm. Sci., 65, 747 (1976). b (dec) = with decomposition.

0 Reproduced from S. Agharkar, S. Lindenbaum and T. Higuchi, J. Pharm. Sci., 65, 747 (1976). b (dec) = with decomposition.

Table 5.14. The increase in the solubility on the formation of the hydrochloride is readily attributable in the case of tetracycline to a lowering of the solution pH by the hydrochloride. The common ion effect can, however, produce an unexpected trend in the solubilities of bases in the presence of high concentrations of hydrochloric acid. Increase in Cl0 concentrations will cause the equilibrium between solid and solution forms

BH+Cl

0 0

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