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Determine major degradation routes

Determine major degradation routes

Aggregation:

- Add surfactants

- Alter buffer conditions or add other excipients to increase solubility

Deamidation:

- Change buffer to reduce rate Tris > NH3 > imidazole - CO2 " Slow rate —> Fast Rate

Oxidation:

- Remove head space O2

- Remove excipients with oxidising agents

- Add antioxidants

Aspartate reactions:

0 0

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