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a Reproduced from B. B. Brodie, in Absorption and Distribution of Drugs (ed. T. Binns), Livingstone, Edinburgh, 1964.

a Reproduced from B. B. Brodie, in Absorption and Distribution of Drugs (ed. T. Binns), Livingstone, Edinburgh, 1964.

Box 9.1 Calculation of percentage ionisation

Absorption values for acetylsalicylic acid at pH 4, 5, 7 and 8 are quoted in Table 9.2. The amount of drug in the unionised form at these pH values is obtained from equation (9.1). For example, at pH 4,

Percentage unionised [U] x 100 100

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