O

5, 7 - diiodo-8-hydroxyquinoline

Figure 10.11 Concentrations of ciprofloxacin in the urine following administration of 50 mg to 12 healthy volunteers in a three-way randomised crossover design by R. W. Frost et al. (Antimicrob. Agents Chemother., 36, 830 (1992)), who write: 'The precise conditions required for ciprofloxacin to form chelate complexes with other cations have not been fully elucidated, but the carboxyl group seems to be the most likely site for chelation. Thus, the gastric pH would need to be elevated sufficiently to ionise the carboxyl group. Therefore, the lack of interaction with dairy products might be attributable to a gastric pH that was not elevated sufficiently to ionise the carboxyl group. Alternatively, it could be due to a decrease in the availability of calcium to chelate ciprofloxacin because of a lipid barrier.'

Gadobenic acid

(Meglumine)

0 0

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