Oh

Salicylic acid

Scheme 4.15 Reactions showing the postulated transacetylation between aspirin and paracetamol and the direct hydrolysis of paracetamol.

Reproduced from B. G. Boggianno et al., Aust. J. Pharm., 51, S14 (1970).

Aspirin-paracetamol-

codeine-talc-magnesium stearate Aspirin-paracetamol-

codeine-talc

BP 1968 free salicyl ic acid limit

Aspirin-paracetamol-

codeine-talc-magnesium stearate Aspirin-paracetamol-

codeine-talc

BP 1968 free salicyl ic acid limit

Aspirin-

paracetamol-

codeine

Aspirin-

phenacetin-codeine

Time (months)

Figure 4.16 Development of free salicylic acid in aspirin-paracetamol-codeine and aspirin-phenacetin-codeine tablets at 37°C.

Reproduced from B. G. Boggianno et al., Aust. J. Pharm., 51, S14 (1970).

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