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Figure 9.16 Buccal absorption of some basic drugs. The drugs were dissolved in buffered solutions of different pH and placed in the mouth of human subjects; absorption rates were determined from the decrease of drug concentration in expelled solutions: □, chlorphenamine (pKa = 8.99); ▼, methadone (pKa = 8.25); x , amfetamine (pKa = 9.94); •, pethidine (pKa # 8.72); nicotine (pKa # 8.02).

Reproduced from A. H. Beckett and E. J. Triggs, J. Pharm. Pharmacol., 19, 31S (1976).

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