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Light and oxygen

We have examined above the stability problems which arise with drugs which are susceptible to photodecomposition or oxidation. We will not reconsider them here but merely re-emphasise that we should take all the necessary precautions to exclude light or oxygen when storing these drugs. In this respect we should remember that water contains dissolved oxygen and so the presence of moisture on the surface of solid preparations may increase the oxidation of susceptible drugs; such drugs must, therefore, be stored under dry conditions.

4.5 Stability testing and prediction of shelf-life

It is clearly most important to be able to ensure that a particular formulation when packaged in a specific container will remain within its physical, chemical, microbiological, therapeutic and toxicological specifications

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