Separation

Figure 12.11 Diagrammatic representation of adhesion between solid surfaces at rest: (a) no adhesive layer; (b) a viscous liquid at the interface; and (c) a semisolid adhesive layer. On separation, the nature of the intervening film is shown: (a) no film, (b) a necking filament of liquid, (c) multiple filaments of the semisolid layer

500 cm3

60 cm3

Figure 12.12 A system for measurement of the force required to detach a solid dosage form from an isolated porcine oesophagus.

Reproduced from reference 9.

Tyrode's solution (electrolyt plus glucose) at 37 °C

60 cm3

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