Solubility-pH profiles of a basic drug (chlor-promazine) and an acidic drug (indometacin) and values for the more complex profile of the amphoteric drug oxytetracycline are plotted in Fig. 5.3.

Despite the widespread use of this approach to predict the pH dependence of drug solubility, it should be noted that a recent study of the accuracy of equation (5.15) in predicting the solubility of a series of cationic drugs as a function of pH in divalent buffer systems

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