Pediatric patient with accidental theophylline overdose

A 3-year, 10-month female child with a two-year history of asthma developed tachynea, respiratory difficulty and fever. She was accidentally given 750mg of theophylline, an amount 10 times in excess of that prescribed. She became restless, developed tachycardia, and vomited coffee-ground material positive for occult blood. Her serum theophylline level was 67 g ml 1 h and 45 min after being given the drug. She was transferred to the intensive care unit. The hospital immediately referred the...

Polyhemoglobintyrosinase for melanoma

We therefore introduce a new approach to chemically crosslinking tyrosinase with an excess of hemoglobin to form a soluble polyhemoglobin-tyrosinase (PolyHb-tyrosinase) complex (Figs. 7.1B, 7.7A). This is similar to the PolyHb-asparaginase as described in Section 7.5. PolyHb-tyrosinase carries out two functions 1) Tyrosinase can remove tyrosine needed for growth by melanoma. With a molar Fig. 7.7. (A) Melanoma needs a higher concentration of tyrosine for growth. Similar to PolyHb-asparaginase,...

Patient with Lesch Nyhan disease

The patient, a 29-month-old boy with severe Lesch-Nyhan disease (HPRT activity less than 3 pmol inositic acid mg protein h) was withdrawn from allopurinol therapy over 5 days. Blood and urine were obtained at 0830 h and 1630 h. After baseline studies for 3 days, the patient was treated with 100 U of XOD artificial cells via a nasogastric tube twice a day (0900 and 1200 h) for 10 days. A sample of his cerebrospinal fluid was obtained at 1630 h before treatment and on the final day of therapy....

Protein coated artificial cells in immunoadsorption

Albumin can bind tightly to the ultrathin collodion membrane of adsorbent artificial cells Chang, 1969a . This was initially used to increase the blood compatibility of the adsorbent artificial cells for hemoperfusion Chang, 1969a . We also applied this albumin coating to synthetic immunosorbents resulting in blood compatible synthetic blood group immunosorbents Chang, 1980d .This albumin-coated synthetic adsorbent has been applied clinically for removing blood group antibodies from plasma for...