First observation of recovery of consciousness in hepatic coma

As shown in acute poisoning patients in the above section, adsorbent artificial cell hemoperfusion is effective in removing suicidal and accidental overdoses of medications in patients. It is also effective in removing other toxic substances from the circulating blood. Its effectiveness in removing hepatic toxins from the circulating blood was first shown in a grade IV hepatic coma patient, with recovery of consciousness within an hour after the initiation of hemoperfusion (Chang, 1972b). A...

Artificial cells containing cells

The first artificial cells containing intact biological cells were reported in 1964 based on a drop method (Chang, 1964), and it was proposed that protected from immunological process, encapsulated endocrine cells might survive and maintain an effective supply of hormone (1965, Chang et al., 1966) (Fig. 2.5). Chang asked Conaught Laboratory of insulin fame to develop this for use in islet transplantation for diabetes. Later, Sun and his collaborator from Conaught Laboratory developed Chang's...

Pediatric patient with accidental theophylline overdose

A 3-year, 10-month female child with a two-year history of asthma developed tachynea, respiratory difficulty and fever. She was accidentally given 750mg of theophylline, an amount 10 times in excess of that prescribed. She became restless, developed tachycardia, and vomited coffee-ground material positive for occult blood. Her serum theophylline level was 67 g ml 1 h and 45 min after being given the drug. She was transferred to the intensive care unit. The hospital immediately referred the...

Polyhemoglobintyrosinase for melanoma

We therefore introduce a new approach to chemically crosslinking tyrosinase with an excess of hemoglobin to form a soluble polyhemoglobin-tyrosinase (PolyHb-tyrosinase) complex (Figs. 7.1B, 7.7A). This is similar to the PolyHb-asparaginase as described in Section 7.5. PolyHb-tyrosinase carries out two functions 1) Tyrosinase can remove tyrosine needed for growth by melanoma. With a molar Fig. 7.7. (A) Melanoma needs a higher concentration of tyrosine for growth. Similar to PolyHb-asparaginase,...