Polysaccharide incorporation

Since natural rbc's and the endothelium of vessels are covered by mucopolysacchride, further experiments were carried out to incorporate a complex containing a mucopolysaccharide (heparin) into the collodion membrane of artificial cells (Chang et al., 1967; Chang, 1970). Preliminary results showed that while both types were removed rapidly from the circulation, those with a heparin-complexed membrane survived significantly longer.

Fig. 5.7. Circulation time of51 Cr labeled artificial rbc (mean diameter, 5^) after intravenous infusion into cats; arterial sampling. Upper line: sulfonated nylon membrane artificial rbc's. Lower line: nylon membrane artificial rbc's. Survival estimated as percentage of radioactivity. (From Chang, 1965,1972a.)

Fig. 5.7. Circulation time of51 Cr labeled artificial rbc (mean diameter, 5^) after intravenous infusion into cats; arterial sampling. Upper line: sulfonated nylon membrane artificial rbc's. Lower line: nylon membrane artificial rbc's. Survival estimated as percentage of radioactivity. (From Chang, 1965,1972a.)

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