Binding Interaction

Any noncovalent association guided by electrostatics and complementarity, in which a smaller solute (known as a ligand) binds to a site on its larger molecular weight binding partner (frequently called a protein, enzyme, or receptor). Although kinetics is the major focus of this handbook, binding is a fundamental step in nearly all kinetic mechanisms. Detailed discussions of equilibrium ligand binding interactions lie beyond the scope of this book, and interested readers are encouraged to...

HoAh2oh

L-Glyceraldehyde ( S)-Glyceraldehyde D-Glyceraldehyde (F )-Glyceraldehyde The dl-system is in common use with respect to amino acids and sugars, but the Cahn-Ingold-Prelog system (the RS-system) is more systematic and should be used. The literature is replete with reports failing to specify the stereochemistry of certain reactions, and one must often infer the enantiomer. See Configuration Cahn-Ingold-Prelog System Corn Rule Diastereomers En-antiomers (R S)-Convention 1J. M. Bijuoet, A. F....

Catalytic Antibodies

Antibodies possessing catalytic activity as a result of their selection using transition state mimics as immuno-genic or antigenic agents. Antibody catalysis takes advantage of the molecular diversity of the immune system and current knowledge of mechanistic enzymology and physical organic chemistry1 , allowing production of novel catalysts for reactions previously lacking biological catalysis. As pointed out by Schultz and Lerner1 , systematic mechanistic and structural investigations of...

Chaperones Chaperonins

Charge Relay Transfer Chymotrypsin

Proteins that assist in the folding or translocation of other proteins1. These specialized proteins possess the ability a to inhibit incorrect folding and or aggregation of newly biosynthesized proteins during and following translation b to target or direct denatured or oxida-tively damaged proteins to lysosomes where they undergo degradation and c to faciltate transmembrane translocation of targeted proteins. Chaperonins frequently carry out their functions through ATP hydrolysis-dependent...