Binding Interaction

Any noncovalent association guided by electrostatics and complementarity, in which a smaller solute (known as a ligand) binds to a site on its larger molecular weight binding partner (frequently called a protein, enzyme, or receptor). Although kinetics is the major focus of this handbook, binding is a fundamental step in nearly all kinetic mechanisms. Detailed discussions of equilibrium ligand binding interactions lie beyond the scope of this book, and interested readers are encouraged to...

Catalytic Antibodies

Antibodies possessing catalytic activity as a result of their selection using transition state mimics as immuno-genic or antigenic agents. Antibody catalysis takes advantage of the molecular diversity of the immune system and current knowledge of mechanistic enzymology and physical organic chemistry1 , allowing production of novel catalysts for reactions previously lacking biological catalysis. As pointed out by Schultz and Lerner1 , systematic mechanistic and structural investigations of...

Chaperones Chaperonins

Charge Relay Transfer Chymotrypsin

Proteins that assist in the folding or translocation of other proteins1. These specialized proteins possess the ability a to inhibit incorrect folding and or aggregation of newly biosynthesized proteins during and following translation b to target or direct denatured or oxida-tively damaged proteins to lysosomes where they undergo degradation and c to faciltate transmembrane translocation of targeted proteins. Chaperonins frequently carry out their functions through ATP hydrolysis-dependent...