Anthranilate Phosphoribosyltransferase

This enzyme [EC 2.4.2.18], also referred to as phospho-ribosyl-anthranilate pyrophosphorylase, catalyzes the reaction of anthranilate with phosphoribosylpyrophos-phate to produce N-5'-phosphoribosylanthranilate and pyrophosphate. In certain species, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan (i.e., indole-3-glycerol-phosphate synthase, anthranilate synthase, tryptophan synthase, and phos-phoribosylanthranilate isomerase).

R. Bentley (1990) Crit. Rev. Biochem. Mol. Biol. 25, 307. R. Bauerle, J. Hess & S. French (1987) Meth. Enzymol. 142, 366. W. D. L. Musick (1981) Crit. Rev. Biochem. 11,1.

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