Bisphosphoglycerate Mutase

This enzyme [EC] (also known as bisphosphoglyc-erate synthase, diphosphoglycerate mutase, and glycer-ate phosphomutase) catalyzes the reversible interconversion of 3-phospho-d-glyceroyl phosphate to 2,3-bisphospho-d-glycerate. The "cofactor" for this enzyme is 3-phosphoglyceroyl phosphate. In the reaction scheme, the enzyme is phosphorylated by this "cofactor" to yield a phosphoenzyme and 3-phosphoglycerate. The latter compound is then rephosphorylated by the enzyme to yield 2,3-bisphosphoglycerate, but this reaction is slowed down by dissociation of 3-phosphoglycerate from the enzyme, which is therefore more active in the presence of added 3-phosphoglycerate.

L. A. Fothergill-Gilmore & H. C. Watson (1989) Adv. Enzymol. 62, 227.

W. J. Ray, Jr., & E. J. Peck, Jr. (1972) The Enzymes, 3rd ed., 6, 407.

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