Modern Antibody Technology The Impact on Drug Development 1147 Simon Moroney and Andreas Pluckthun

2.1 Introduction 1147

2.2 Immunogenicity 1148

2.3 Technology 1153

2.4 Reaching the Target: The Importance of Specificity, Affinity and Format 1163

2.5 Exerting an Effect at the Target 1168

2.6 Antibodies in their Natural Habitat: Infectious Diseases 1175

2.7 Opportunities for New Therapeutic Applications Provided by Synthetic Antibodies 1176

2.8 Future Directions and Concluding Statements 1177

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