Myocardial Regeneration Strategies using Human Embryonic Stem Cells 283

Izhak Kehat, Oren Caspi, and Lior Gepstein

12.1 Introduction 284

12.2 Derivation of Human Embryonic Stem Cells 286

12.3 Cardiomyocyte Differentiation of ES Cells 289

12.4 Possible Research and Clinical Applications of the hES-derived Cardiomyocytes 293

12.5 Early Cardiac Lineage Differentiation 293

12.6 Myocardial Regeneration Strategies using hES-derived Cardiomyocytes 295

12.7 Functional Integration of the Cell Grafts 296

12.8 Cardiomyocyte Enrichment, Purification, and Up-scaling Strategies 298

12.9 Prevention of Immunological Rejection 299

12.10 Conclusions 300

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