Abc Transporters In Drug Absorption And Elimination

Systemic exposure to orally administered digoxin is increased by coadministration of MDR1 inducers and negatively correlated with MDR1 protein expression in the intestine. MDR1 is also expressed on the brush-border membrane of renal epithelia, and its function can be monitored using digoxin (>70% excreted in the urine). MDR1 inhibitors (e.g., quinidine, verapamil, vaspo-dar, spironolactone, clarithromycin, and ritonavir) all markedly reduce renal digoxin excretion. In view of this, drugs with narrow therapeutic windows (e.g., digoxin) should be used with great care if MDR1-based drug-drug interactions are likely.

ABC Transporters Involved in Drug Absorption, Distribution, and Excretion

Transporter Name Tissue Distribution

Physiological Function

Substrates

MDR1 (ABCB1)

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

Get My Free Ebook


Post a comment