Guanadrel is rapidly absorbed, leading to maximal levels in plasma at 1—2 hours. Because gua-nadrel must be transported into and accumulate in adrenergic neurons, the maximum effect on blood pressure is not seen until 4—5 hours. Although the ¡3 phase of its elimination has a t/2 of ~5—10 hours, this almost certainly does not reflect the longer t/2 of drug stored at its site of action in the secretory vesicles of adrenergic neurons. The t122 of the pharmacological effect of guanadrel is determined by the drug's persistence in this neuronal pool and is probably at least 10 hours. Guanadrel is administered in a regimen of twice-daily doses.
Guanadrel is cleared by both renal and nonrenal disposition. Its elimination is impaired in patients with renal insufficiency; total-body clearance is reduced by four- to fivefold in patients with severe renal dysfunction.
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Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...