Absorption Distribution Metabolism And Excretion

Guanadrel is rapidly absorbed, leading to maximal levels in plasma at 1โ€”2 hours. Because gua-nadrel must be transported into and accumulate in adrenergic neurons, the maximum effect on blood pressure is not seen until 4โ€”5 hours. Although the ยก3 phase of its elimination has a t/2 of ~5โ€”10 hours, this almost certainly does not reflect the longer t/2 of drug stored at its site of action in the secretory vesicles of adrenergic neurons. The t122 of the pharmacological effect of guanadrel is determined by the drug's persistence in this neuronal pool and is probably at least 10 hours. Guanadrel is administered in a regimen of twice-daily doses.

Guanadrel is cleared by both renal and nonrenal disposition. Its elimination is impaired in patients with renal insufficiency; total-body clearance is reduced by four- to fivefold in patients with severe renal dysfunction.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment