Absorption Fate And Excretion

Absorption of quaternary ammonium and sulfonium compounds from the GI tract is incomplete and unpredictable, due to the limited ability of these ionized substances to penetrate cell membranes and depression of propulsive movements of the small intestine and gastric emptying.

Absorption of mecamylamine is less erratic, but reduced bowel activity and paralytic ileus are a danger. After absorption, the quaternary ammonium- and sulfonium-blocking agents are confined primarily to the extracellular space and are excreted mostly unchanged by the kidney. Mecamylamine concentrates in the liver and kidney and is excreted slowly in an unchanged form.

Was this article helpful?

0 0
101 Power Tips For Preventing and Treating Headaches

101 Power Tips For Preventing and Treating Headaches

Are you fed up with your frequent headache pain? 101 Simple Ways to Attack Your Headache BEFORE the Pain Starts Guaranteed No Pain, No Fear, Full Control Normal Life Again Headaches can stop you from doing all the things you love. Seeing friends, playing with the kids... even trying to watch your favorite television shows.

Get My Free Ebook

Post a comment