The antibacterial spectrum of trimethoprim resembles that of sulfamethoxazole. Most gramnegative and gram-positive microorganisms are sensitive to trimethoprim, but there is significant regional variation in the susceptibility of Enterobacteriaceae to trimethoprim because of the spread of resistance.
Efficacy of Trimethoprim-Sulfamethoxazole in Combination
A synergistic interaction between these drugs is apparent even when microorganisms are resistant to sulfonamide, but maximal synergism occurs when microorganisms are sensitive to both drugs.
Was this article helpful?
Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...