Antibacterial Spectrum

The antibacterial spectrum of trimethoprim resembles that of sulfamethoxazole. Most gramnegative and gram-positive microorganisms are sensitive to trimethoprim, but there is significant regional variation in the susceptibility of Enterobacteriaceae to trimethoprim because of the spread of resistance.

Efficacy of Trimethoprim-Sulfamethoxazole in Combination

A synergistic interaction between these drugs is apparent even when microorganisms are resistant to sulfonamide, but maximal synergism occurs when microorganisms are sensitive to both drugs.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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