Apraclonidine (iopidine) is a relatively selective a2 agonist that is used topically to reduce intraocular pressure with minimal systemic effects; apraclonidine seems not to cross the blood—brain barrier and is more useful than clonidine for ophthalmic therapy. The drug is useful as short-term adjunctive therapy in glaucoma patients whose intraocular pressure is not well controlled by other pharmacological agents and to control or prevent elevations in intraocular pressure that occur in patients after laser trabeculoplasty or iridotomy (see Chapter 63).

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