Artemisinin And Derivatives

The artemisinins are potent antimalarials with no clinical evidence of resistance. They are particularly well suited for the treatment of severe P. falciparum malaria and play a key role in combination therapy of drug-resistant infections. They are not FDA approved, and inactive counterfeits are common.

ANTIPARASITIC ACTIVITY Extensive structure-activity studies have confirmed the requirement for an endoperoxide moiety for antimalarial activity. These drugs act rapidly against the asexual erythrocytic stages of P. vivax and P. falciparum. Their potency in vivo is 10- to 100-fold greater than that of other antimalarials. They are not cross-resistant with other drugs; indeed, sensitivity to the artemisinins may be increased in chloroquine-resistant parasites. When used alone, the artemisinins are associated with a high level of parasite recrudescence, which may be related to their rapid metabolism. They have gametocytocidal activity but do not affect either primary or

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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