Cardiovascular Effects

The cardiovascular effects of racemic dobutamine are a composite of the pharmacological properties of the (—) and (+) stereoisomers. Dobutamine has relatively more prominent inotropic than chronotropic effects, compared to isoproterenol. This useful selectivity may arise because peripheral resistance is relatively unchanged due to a counterbalancing of a1 receptor—mediated vasoconstriction and b2 receptor—mediated vasodilation. Alternatively, cardiac a1 receptors may contribute to the inotropic effect. At equivalent inotropic doses, dobutamine enhances automatic-ity of the sinus node to a lesser extent than does isoproterenol; however, enhancement of AV and intraventricular conduction is similar for both drugs.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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