Cardiovascular System

The classical response of blood vessels to 5-HT is contraction, particularly in the splanchnic, renal, pulmonary, and cerebral vasculatures. This response also occurs in bronchial smooth muscle. 5-HT induces a variety of cardiac responses that result from activation of multiple 5-HT receptor subtypes, stimulation or inhibition of autonomic nerve activity, and reflex responses to 5-HT. Thus, 5-HT has positive inotropic and chronotropic actions on the heart that may be blunted

by simultaneous stimulation of afferent

nerves from baroreceptors and chemoreceptors. An effect

Table 11-2

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