Chemistry And Structureactivity Relationships Noncovalent Inhibitors

These agents share mechanism (above and Figure 8-1) but differ in their disposition in the body and their affinity for the enzyme. Edrophonium, a quaternary drug whose activity is limited to peripheral nervous system synapses, has a moderate affinity for AChE. Its volume of distribution is limited and renal elimination is rapid, accounting for its short duration of action. By contrast, tacrine and donepezil (Figure 8-2) have higher affinities for AChE and are more hydrophobic, contributing to their longer durations of action; they readily cross the blood-brain barrier to inhibit AChE in the central nervous system (CNS).

Was this article helpful?

0 0
Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment