Chloroprocaine (nesacaine), an ester local anesthetic, is a chlorinated derivative of procaine with rapid onset, short duration of action, and reduced acute toxicity due to rapid metabolism (plasma t1/2 ~25 seconds). A higher-than-expected incidence of muscular back pain following epidural anesthesia with 2-chloroprocaine has been reported; this back pain is thought to be due to tetany in the paraspinus muscles, which may be a consequence of Ca2+ binding by the EDTA included as a preservative; the incidence of back pain appears to be related to the volume of drug injected and its use for skin infiltration.
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Tired Having Back Pains All The Time, But You Choose To Ignore It? Every year millions of people see their lives and favorite activities limited by back pain. They forego activities they once loved because of it and in some cases may not even be able to perform their job as well as they once could due to back pain.